curacozole

Term ID

CHEBI:156428

Synonyms

• 20,23-di(butan-2-yl)-4-methyl-16-phenyl-3,15,28-trioxa-7,11-dithia-19,22,25,30,31,32,33,34-octaazahexacyclo[25.2.1.1(2,5).1(6,9).1(10,13).1(14,17)]tetratriaconta-1(29),2(34),4,6(33),8,10(32),12,14(31),16,27(30)-decaene-18,21,24-trione

Definition

An azamacrocycle obtained from a core peptide of sequence Phe-Ile-Ile-Gly-Ser-Thr-Cys-Cys encoded in the genome of several Streptomyces species. It exhibits potent cytotoxic activity against HCT116 and HOS cancer cells.

References

• PMID:30310179

Ontology

ChEBI  ( EBI )