colibactin

Term ID

CHEBI:156303

Synonyms

2-{6-[(2S)-2-methyl-3,4-dihydro-2H-pyrrol-5-yl]-5-oxo-4-azaspiro[2.4]hept-6-en-7-yl}-N-({4-[{4-[(2-{6-[(2S)-2-methyl-3,4-dihydro-2H-pyrrol-5-yl]-5-oxo-4-azaspiro[2.4]hept-6-en-7-yl}acetamido)acetyl]-1,3-thiazol-2-yl}(oxo)acetyl]-1,3-thiazol-2-yl}methyl)ac

Definition

A member of the class of 1,3-thiazoles that comprises of two units of 2-[(2-{6-[(2S)-2-methyl-3,4-dihydro-2H-pyrrol-5-yl]-5-oxo-4-azaspiro[2.4]hept-6-en-7-yl}acetamido)methyl]-1,3-thiazole-4-carboxylic acid linked together via the formal condensation of the carboxy groups. It is a secondary metabolite produced by certain strains of bacteria found in the human gut such as Escherichia coli. It has the ability to bind covalently to DNA and is strongly associated with colorectal cancer.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: 1,3-thiazoles azaspiro compound polyketide pyrroline secondary carboxamide

1,3-thiazoles azaspiro compound polyketide pyrroline secondary carboxamide Show first 5 Terms
has_role: alkylating agent carcinogenic agent Escherichia coli metabolite genotoxin

alkylating agent carcinogenic agent Escherichia coli metabolite genotoxin Show first 5 Terms

Phenotype

Phenotype resulting from colibactin

Phenotype where environments contain colibactin

Phenotype modified by environments containing colibactin

Human Disease Model