decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone

Term ID

CHEBI:156289

Synonyms

dec-RVKR-cmk
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
decanoyl-RVKR-CMK
N(2)-(1-oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-lysinamide
N(2)-decanoyl-L-arginyl-L-valyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-lysinamide

Definition

A tetrapeptide consisting of N-decanoyl-L-arginine, L-valine, L-lysine, and L-arginine joined in sequence by peptide linkages and in which the carboxy group at the C-terminus is substituted by a chloroacetyl group. It is a furin inhibitor that has antiviral activity against Chikungunya virus, Zika virus and Japanese encephalitis virus.

References

cas:150113-99-8
pubmed:12794637
pubmed:15161629
pubmed:15584904
pubmed:17043102
pubmed:17905609
pubmed:19167455
pubmed:19285038
pubmed:20224189
pubmed:21967573
pubmed:22925071
pubmed:24359257
pubmed:25050844
pubmed:25350918
pubmed:25562508
pubmed:28013223
pubmed:30021905
pubmed:31358531
pubmed:31683742

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone

Phenotype where environments contain decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone

Phenotype modified by environments containing decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone

Phenotype affecting decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone

Human Disease Model