Search Ontology:
ChEBI
PD-166866
- Term ID
- CHEBI:156259
- Synonyms
-
- 1-[2-amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea
- 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
- N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea
- PD 166866
- PD-166866
- PD166866
- Definition
- A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by an amino group at position 2, 3,5-dimethoxyphenyl group at position 6, and by a (tert-butylcarbamoyl)nitrilo group at position 7. It is a selective ATP competitive inhibitor of the human fibroblast growth factor-1 receptor (FGFR1) tyrosine kinase with an IC50 of 52.4 nM.
- References
-
- cas:192705-79-6
- pubmed:11063616
- pubmed:11384237
- pubmed:11404258
- pubmed:12805413
- pubmed:15773903
- pubmed:15780636
- pubmed:17964795
- pubmed:17987803
- pubmed:20003343
- pubmed:21967732
- pubmed:22876277
- pubmed:23421678
- pubmed:24719266
- pubmed:26993162
- pubmed:32572027
- pubmed:9655904
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from PD-166866
Phenotype where environments contain PD-166866
Phenotype modified by environments containing PD-166866
Phenotype affecting PD-166866
Human Disease Model