Search Ontology:
ChEBI

PD-166866

Term ID
CHEBI:156259
Synonyms
  • 1-[2-amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea
  • 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
  • N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea
  • PD 166866
  • PD-166866
  • PD166866
(all 6)
Definition
A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by an amino group at position 2, 3,5-dimethoxyphenyl group at position 6, and by a (tert-butylcarbamoyl)nitrilo group at position 7. It is a selective ATP competitive inhibitor of the human fibroblast growth factor-1 receptor (FGFR1) tyrosine kinase with an IC50 of 52.4 nM.
References
(all 17)
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from PD-166866
No data available
Phenotype where environments contain PD-166866
No data available
Phenotype modified by environments containing PD-166866
Phenotype affecting PD-166866
No data available
Human Disease Model
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.