ascofuranone

Term ID

CHEBI:156148

Synonyms

(-)-ascofuranone
(S)-ascofuranone
(S-(E,E))-3-chloro-4,6-dihydroxy-2-methyl-5-(3-methyl-7-(tetrahydro-5,5-dimethyl-4-oxo-2-furanyl)-2,6-octadienyl)-benzaldehyde
3-chloro-5-{(2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl}-4,6-dihydroxy-2-methylbenzaldehyde
ascofuranon

Definition

A dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by the soil fungus, Acremonium sclerotigenum. It is a promising drug candidate against the tropical disease, African trypanosomiasis.

References

cas:38462-04-3
knapsack:C00017973
pubmed:10511901
pubmed:12798927
pubmed:16288933
pubmed:17114644
pubmed:19306296
pubmed:20460103
pubmed:20587660
pubmed:20978157
pubmed:22580003
pubmed:23180806
pubmed:24096035
pubmed:27804952
pubmed:28207754
pubmed:30952781
pubmed:32439259
pubmed:32488849
pubmed:3417568
pubmed:4792115
pubmed:8898329
pubmed:9084049
wikipedia.en:Ascofuranone

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from ascofuranone

Phenotype where environments contain ascofuranone

Phenotype modified by environments containing ascofuranone

Phenotype affecting ascofuranone

Human Disease Model