cenicriviroc

Term ID

CHEBI:149636

Synonyms

• (5E)-8-[4-(2-butoxyethoxy)phenyl]-1-(2-methylpropyl)-N-(4-{(S)-[(1-propyl-1H-imidazol-5-yl)methyl]sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide
• cenicriviroc
• cenicrivirocum
• CVC
• TAK-652
• TBR 652
• TBR-652

Definition

A member of the class of benzazocines that is (5Z)-1,2,3,4-tetrahydro-1-benzazocine which is substituted by a 2-methylpropyl, N-{4-[(S)-(1-propyl-1H-imidazol-5-yl)methanesulfinyl]phenyl}carboxamide and 4-(2-butoxyethoxy)phenyl groups at positions 1, 5 and 8, respectively. It is a potent chemokine 2 and 5 receptor antagonist currently in development for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis (NASH).

References

• cas:497223-25-3
• drugbank:DB11758
• kegg.drug:D09878
• pubmed:16251299
• pubmed:20721836
• pubmed:25394040
• pubmed:26247470
• pubmed:26525792
• pubmed:27169903
• pubmed:28940700
• pubmed:29448843
• pubmed:29561896
• pubmed:30088682
• pubmed:30135687
• pubmed:30179264
• pubmed:30239650
• pubmed:30622370
• pubmed:31312356
• pubmed:31629375
• pubmed:31661521
• pubmed:31680767
• pubmed:31731005
• pubmed:31881392
• pubmed:31943293
• pubmed:32013805
• pubmed:32269742
• wikipedia.en:Cenicriviroc

Ontology

ChEBI  ( EBI )