Search Ontology:
ChEBI

tideglusib

Term ID
CHEBI:147398
Synonyms
  • 4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
  • NP 031112
  • NP-031112
  • NP-12
  • NP031112
  • Nypta
  • tideglusib
  • tideglusibum
  • Zentylor
Definition
A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from tideglusib
Phenotype where environments contain tideglusib
Phenotype modified by environments containing tideglusib
Human Disease Model
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