Search Ontology:
ChEBI
tideglusib
- Term ID
- CHEBI:147398
- Synonyms
-
- 4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
- NP 031112
- NP-031112
- NP-12
- NP031112
- Nypta
- tideglusib
- tideglusibum
- Zentylor
- Definition
- A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3β (GSK3β) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy.
- References
-
- cas:865854-05-3
- drugbank:DB12129
- pubmed:17522320
- pubmed:22936007
- pubmed:24488721
- pubmed:24532007
- pubmed:25537011
- pubmed:26289787
- pubmed:26398371
- pubmed:27378458
- pubmed:27490211
- pubmed:28982059
- pubmed:29388174
- pubmed:29431064
- pubmed:29603837
- pubmed:30574063
- pubmed:30666199
- pubmed:30965670
- pubmed:31156177
- pubmed:32195836
- wikipedia.en:Tideglusib
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from tideglusib
Phenotype where environments contain tideglusib
Phenotype modified by environments containing tideglusib
Phenotype affecting tideglusib
Human Disease Model