GS-441524

Term ID

CHEBI:147281

Synonyms

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
EVO 984
EVO-984
EVO984
GS 441524
GS441524

Definition

A C-nucleoside analog that is (2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile substituted by a 4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl group at position 2. It is the active metabolite of remdesivir and exhibits a broad range of inhibitory activity against various RNA viruses including HCV, parainfluenza and SARS-CoV.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic amine C-nucleoside nitrile pyrrolotriazine

aromatic amine C-nucleoside nitrile pyrrolotriazine Show first 5 Terms
has_role: anticoronaviral agent antiviral agent drug metabolite

anticoronaviral agent antiviral agent drug metabolite Show first 5 Terms
inverse has_functional_parent: GS-441524 monophosphate GS-443902 remdesivir

GS-441524 monophosphate GS-443902 remdesivir Show first 5 Terms

Phenotype

Phenotype resulting from GS-441524

Phenotype where environments contain GS-441524

Phenotype modified by environments containing GS-441524

Human Disease Model