palytoxin

Term ID

CHEBI:146207

Synonyms

• (2S,3R,5R,6E,8R,9S)-10-[(2R,3R,4R,5S,6R)-6-[(1S,2R,3S,4S,5R,11S)-11-{[(1R,3S,5S,7R)-5-[(8S)-9-[(2R,3R,4R,5R,6S)-6-[(2S,3S,4E,6S,9R,10R)-10-[(2S,4R,5S,6R)-6-[(2R,3R)-4-[(2R,3S,4R,5R,6S)-6-[(2S,3Z,5E,8R,9S,10R,12Z,17S,18R,19R,20R)-20-{[(2R,3R,4R,5S,6R)-6-[(
• (2S,3R,5R,6E,8R,9S)-10-[(2R,3R,4R,5S,6R)-6-{(1S,2R,3S,4S,5R,11S)-12-[(1R,3S,5S,7R)-5-{(8S)-9-[(2R,3R,4R,5R,6S)-6-{(2S,3S,4E,6S,9R,10R)-10-[(2S,4R,5S,6R)-6-{(2R,3R)-4-[(2R,3S,4R,5R,6S)-6-{(2S,3Z,5E,8R,9S,10R,12Z,17S,18R,19R,20R)-21-[(2R,3R,4R,5S,6R)-6-{(1Z
• PLTX
• PTX

Definition

A polyol marine coelenterate toxin composed of substituted N-3-hydroxypropyl-trans-3-amidoacrylamides and produced by species of Palythoa and Zoanthus soft corals (collectively called zoantharians), either as a defence mechanism or to assist them in capturing prey. An ionophore that forms cation channels through Na+/K+-ATPase, it is a potent vasoconstrictor useful in evaluation of anti-angina agents. It is considered to be one of the most poisonous non-protein substances known, second only to maitotoxin in terms of toxicity in mice.

References

• cas:11077-03-5
• cas:77734-91-9
• pubmed:1354900
• pubmed:23442788
• pubmed:26489638
• pubmed:26587298
• pubmed:26861356
• pubmed:27129894
• pubmed:27343702
• pubmed:27793603
• pubmed:27816587
• pubmed:27843763
• pubmed:28648045
• pubmed:28843098
• pubmed:29110038
• pubmed:29611245
• pubmed:29657808
• pubmed:29902540
• pubmed:30090423
• pubmed:30110919
• pubmed:30475097
• pubmed:30528507
• pubmed:30558165
• pubmed:30956217
• pubmed:31664144
• pubmed:32056831

Ontology

ChEBI  ( EBI )

Resources

CTD