remdesivir

Term ID

CHEBI:145994

Synonyms

• (2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester
• 2-ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
• 2-ethylbutyl N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate
• GS 5734
• GS-5734
• GS5734
• remdesivir
• remdesivirum

Definition

A carboxylic ester resulting from the formal condensation of the carboxy group of N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alanine with the hydroxy group of 2-ethylbutan-1-ol. A broad-spectrum antiviral prodrug with potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. It is currently in Phase III clinical trials for the treatment of Covid-19 in adults.

References

• cas:1809249-37-3
• drugbank:DB14761
• kegg.drug:D11472
• pmc:PMC5630887
• pubmed:26934220
• pubmed:28124907
• pubmed:28262699
• pubmed:28659436
• pubmed:29511076
• pubmed:30275474
• pubmed:30987343
• pubmed:31142680
• pubmed:31233808
• pubmed:31924756
• pubmed:32020029
• pubmed:32054787
• pubmed:32094225
• pubmed:32145386
• pubmed:32147516
• pubmed:32152082
• wikipedia.en:Remdesivir

Ontology

ChEBI  ( EBI )