Search Ontology:
ChEBI
AS1842856
- Term ID
- CHEBI:145800
- Synonyms
-
- 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
- 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
- AS 1842856
- AS-1842856
- FOXO1 inhibitor
- Definition
- A quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations.
- References
-
- cas:836620-48-5
- pubmed:20736318
- pubmed:24807827
- pubmed:25483084
- pubmed:26239835
- pubmed:26502358
- pubmed:27260854
- pubmed:28215713
- pubmed:28687587
- pubmed:28888048
- pubmed:29157981
- pubmed:30404794
- pubmed:30611853
- pubmed:31042779
- pubmed:31085234
- pubmed:31146723
- pubmed:31298345
- pubmed:31557894
- pubmed:31579588
- pubmed:31655022
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from AS1842856
Phenotype where environments contain AS1842856
Phenotype modified by environments containing AS1842856
Phenotype affecting AS1842856
Human Disease Model