Search Ontology:
ChEBI
pevonedistat
- Term ID
- CHEBI:145535
- Synonyms
-
- [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxy-cyclopentyl]methyl sulfamate
- [(1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate
- MLN 4924
- MLN-4924
- MLN4924
- pevonedistat
- pevonedistatum
- Definition
- A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine which is substituted by a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group at position 4 and by a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group at position 7. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, and currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes.
- References
-
- cas:905579-51-3
- drugbank:DB11759
- kegg.drug:D10413
- lincs.smallmolecule:LSM-6263
- pdb-ccd:B39
- pubmed:19360080
- pubmed:20129059
- pubmed:25733005
- pubmed:26292710
- pubmed:26561559
- pubmed:27551465
- pubmed:27783255
- pubmed:27901050
- pubmed:28578874
- pubmed:28717191
- pubmed:28838998
- pubmed:29348128
- pubmed:29667067
- pubmed:30020196
- pubmed:30341788
- pubmed:30545630
- pubmed:30556867
- pubmed:30845347
- pubmed:30850948
- pubmed:31002342
- pubmed:31355467
- pubmed:31528694
- pubmed:31665821
- wikipedia.en:Pevonedistat
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from pevonedistat
Phenotype where environments contain pevonedistat
Phenotype modified by environments containing pevonedistat
Phenotype affecting pevonedistat
Human Disease Model