ivosidenib

Term ID

CHEBI:145430

Synonyms

• (2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
• AG-120
• ivosidenib
• ivosidenibum
• N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxo-L-prolinamide
• Tibsovo

Definition

A tertiary carboxamide resulting from the formal condensation of the carboxy group of (2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidine-2-carboxylic acid with the secondary amino group of (2S)-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-2-[(5-fluoropyridin-3-yl)amino]acetamide. It is approved by the FDA for the treatment of acute myeloid leukemia (AML) in patients with an isocitrate dehydrogenase-1 (IDH1) mutation.

References

• cas:1448347-49-6
• drugbank:DB14568
• kegg.drug:D11090
• pmc:PMC6217633
• pubmed:27245312
• pubmed:29670690
• pubmed:29860938
• pubmed:29925981
• pubmed:29934313
• pubmed:30093505
• pubmed:30209701
• pubmed:30222290
• pubmed:30231226
• pubmed:30260154
• pubmed:30260155
• pubmed:30610623
• pubmed:30692099
• pubmed:30758648
• pubmed:30822797
• pubmed:31011758
• pubmed:31028664
• pubmed:31300360
• pubmed:31382862
• wikipedia.en:Ivosidenib

Ontology

ChEBI  ( EBI )