Search Ontology:
ChEBI
rigosertib
- Term ID
- CHEBI:145417
- Synonyms
-
- (E)-ON 01910
- [2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)anilino]acetic acid
- N-[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine
- ON 01910
- ON-01910
- rigosertib
- rigosertibum
- Definition
- An N-[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine in which the double bond has E-configuration. It is a non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM and exhibits anti-cancer properties.
- References
-
- cas:592542-59-1
- drugbank:DB12146
- kegg.drug:D10154
- lincs.smallmolecule:LSM-44531
- pdb-ccd:6FS
- pubmed:15766665
- pubmed:16223707
- pubmed:27150054
- pubmed:27764820
- pubmed:28985505
- pubmed:29070108
- pubmed:29144985
- pubmed:30956775
- pubmed:31299161
- pubmed:31312928
- wikipedia.en:Rigosertib
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from rigosertib
Phenotype where environments contain rigosertib
Phenotype modified by environments containing rigosertib
Phenotype affecting rigosertib
Human Disease Model