enasidenib

Term ID

CHEBI:145374

Synonyms

2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol
AG 221
AG-221
CC-90007
enasidenib
enasidenibum
Idhifa

Definition

A 1,3,5-triazine which is substituted by (2-hydroxy-2-methylpropyl)nitrilo, 6-(trifluoromethyl)pyridin-2-yl and [2-(trifluoromethyl)pyridin-4-yl]nitrilo groups at positions 2,4 and 6, respectively. It is an isocitrate dehydrogenase-2 (IDH2) inhibitor which has been approved for the treatment of adults with relapsed or refractory acute myeloid leukaemia (AML).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: 1,3,5-triazines aminopyridine aromatic amine organofluorine compound secondary amino compound ... Show All 6 Terms

1,3,5-triazines aminopyridine aromatic amine organofluorine compound secondary amino compound tertiary alcohol Show first 5 Terms
has_role: antineoplastic agent EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor

antineoplastic agent EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from enasidenib

Phenotype where environments contain enasidenib

Phenotype modified by environments containing enasidenib

Human Disease / Model Data

Citations