enasidenib

Term ID

CHEBI:145374

Synonyms

• 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol
• AG 221
• AG-221
• CC-90007
• enasidenib
• enasidenibum
• Idhifa

Definition

A 1,3,5-triazine which is substituted by (2-hydroxy-2-methylpropyl)nitrilo, 6-(trifluoromethyl)pyridin-2-yl and [2-(trifluoromethyl)pyridin-4-yl]nitrilo groups at positions 2,4 and 6, respectively. It is an isocitrate dehydrogenase-2 (IDH2) inhibitor which has been approved for the treatment of adults with relapsed or refractory acute myeloid leukaemia (AML).

References

• cas:1446502-11-9
• drugbank:DB13874
• kegg.drug:D10901
• pdb-ccd:69Q
• pubmed:28193778
• pubmed:28280273
• pubmed:28461409
• pubmed:28659444
• pubmed:28818952
• pubmed:28879540
• pubmed:29320949
• pubmed:29742078
• pubmed:29770715
• pubmed:29803908
• pubmed:30013764
• pubmed:30069631
• pubmed:30360730
• pubmed:30386625
• pubmed:30663096
• pubmed:30719396
• pubmed:30858735
• pubmed:30967620
• pubmed:31118877
• pubmed:31454277
• pubmed:31564968
• pubmed:31652462
• wikipedia.en:Enasidenib

Ontology

ChEBI  ( EBI )