gilteritinib

Term ID

CHEBI:145372

Synonyms

6-ethyl-3-((3-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)-2-pyrazinecarboxamide
6-ethyl-3-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide
6-ethyl-3-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-5-[(oxan-4-yl)amino]pyrazine-2-carboxamide
ASP 2215
ASP-2215
ASP2215
gilteritinib
gilteritinibum
Xospata

Definition

A member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic amine monomethoxybenzene N-methylpiperazine oxanes piperidines ... Show All 8 Terms

aromatic amine monomethoxybenzene N-methylpiperazine oxanes piperidines primary carboxamide pyrazines secondary amino compound Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor

antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from gilteritinib

Phenotype where environments contain gilteritinib

Phenotype modified by environments containing gilteritinib

Human Disease / Model Data