Search Ontology:
ChEBI
dinophysistoxin 1
- Term ID
- CHEBI:144400
- Synonyms
-
- (2R)-3-[(2S,5R,6R,8S)-8-{(2R,3E)-4-[(2R,4a'R,5R,6'S,8'R,8a'S)-6'-{(1S,3S)-3-[(2S,3R,6R,11R)-3,11-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-1-hydroxybutyl}-8'-hydroxy-7'-methylideneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl}-5
- 35-Methylokadaic acid
- Dinophysistoxin-1
- DTX 1
- DTX-1
- DTX1
- Definition
- A ketal that is a marine toxin structurally related to okadaic acid. Produced by dinoflagellates it is known to accumulate in shellfish and cause diarrhoeic shellfish poisoning. It is an inhibitor of serine/threonine protein phosphatases 1 (PP1) and PP2A and has been shown to promote cancer cell growth in tumour cell lines and animal models.
- References
-
- cas:81720-10-7
- foodb.food:FDB002306
- hmdb:HMDB0030442
- kegg.compound:C16870
- knapsack:C00044717
- pubmed:10398517
- pubmed:17455957
- pubmed:1905699
- pubmed:19481560
- pubmed:23127709
- pubmed:24394641
- pubmed:25238672
- pubmed:25826053
- pubmed:26426049
- pubmed:27956244
- pubmed:28366404
- pubmed:29491228
- pubmed:30176657
- pubmed:30884396
- pubmed:3564062
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from dinophysistoxin 1
Phenotype where environments contain dinophysistoxin 1
Phenotype modified by environments containing dinophysistoxin 1
Phenotype affecting dinophysistoxin 1
Human Disease Model