lorlatinib

Term ID

CHEBI:143117

Synonyms

• (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
• loratinib
• Lorbrena
• lorlatinib
• lorlatinibum
• PF-06463922
• PF06463922
• PFE-PKIS 10

Definition

A cyclic ether that is 16,17-dihydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one substituted by methyl groups at positions 2 and 10R, and by cyano, amino and fluoro groups at positions 3, 7 and 12 respectively. It is a small molecule inhibitor of ALK and ROS1 kinase developed by Pfizer for the treatment of ALK-positive non-small cell lung cancer.

References

• cas:1454846-35-5
• drugbank:DB12130
• kegg.drug:D11012
• pdb-ccd:5P8
• pubmed:24819116
• pubmed:25073473
• pubmed:25349124
• pubmed:25733882
• pubmed:26698910
• pubmed:26880581
• pubmed:27413712
• pubmed:28594000
• pubmed:29744867
• pubmed:30413378
• pubmed:30478428
• pubmed:30604291
• pubmed:30816885
• wikipedia.en:Lorlatinib

Ontology

ChEBI  ( EBI )