Search Ontology:
ChEBI

lorlatinib

Term ID
CHEBI:143117
Synonyms
  • (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
  • loratinib
  • Lorbrena
  • lorlatinib
  • lorlatinibum
  • PF-06463922
  • PF06463922
  • PFE-PKIS 10
Definition
A cyclic ether that is 16,17-dihydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one substituted by methyl groups at positions 2 and 10R, and by cyano, amino and fluoro groups at positions 3, 7 and 12 respectively. It is a small molecule inhibitor of ALK and ROS1 kinase developed by Pfizer for the treatment of ALK-positive non-small cell lung cancer.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from lorlatinib
Phenotype where environments contain lorlatinib
Phenotype modified by environments containing lorlatinib
Human Disease Model
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