andrastin B

Term ID

CHEBI:142862

Synonyms

methyl (3beta,5beta,8alpha,9beta,10alpha,13alpha)-3-(acetyloxy)-15,19-dihydroxy-4,4,8,12,16-pentamethyl-17-oxoandrosta-11,15-diene-14-carboxylate
methyl 3beta-(acetyloxy)-15,19-dihydroxy-4,4,8,12,16-pentamethyl-17-oxo-5beta,8alpha,9beta,10alpha,13alpha-androsta-11,15-diene-14-carboxylate

Definition

A 17-oxo steroid that is andrastin C in which a hydrogen of the methyl group at position 19 has been replaced by a hydroxy group. A farnesyltransferase inhibitor produced by Penicillium roqueforti, a filamentous fungus involved in the ripening of several kinds of blue cheeses.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: 5beta steroid 15-hydroxy steroid 17-oxo steroid 19-hydroxy steroid acetate ester ... Show All 9 Terms

5beta steroid 15-hydroxy steroid 17-oxo steroid 19-hydroxy steroid acetate ester enol meroterpenoid methyl ester primary alcohol Show first 5 Terms
has_functional_parent: andrastin C

andrastin C Show first 5 Terms
has_role: EC 2.5.1.58 (protein farnesyltransferase) inhibitor Penicillium metabolite

EC 2.5.1.58 (protein farnesyltransferase) inhibitor Penicillium metabolite Show first 5 Terms
inverse has_functional_parent: andrastin A

andrastin A Show first 5 Terms
inverse is_conjugate_base_of: andrastin B(1-)

andrastin B(1-) Show first 5 Terms
is_conjugate_acid_of: andrastin B(1-)

andrastin B(1-) Show first 5 Terms

Phenotype

Phenotype resulting from andrastin B

Phenotype where environments contain andrastin B

Phenotype modified by environments containing andrastin B

Human Disease Model