Search Ontology:
ChEBI

omega-conotoxin MVIIA

Term ID
CHEBI:142406
Synonyms
  • omega-Conopeptide MVIIA (Conus)
  • SNX-111
  • ziconotide
Definition
A heterodetic cyclic polypeptide consisting of the linear sequence Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 with three disulfide bridges between cysteine residues 1-16, 8-20 and 15-25. A neuronal N-type Ca(2+) channel blocker in mammalian and amphibian brain, it blocks release of GABA and glutamate at neuronal synapses. Used as a probe for calcium channel receptors, it is selective for different receptor subtypes. A synthetic form, named ziconotide, is an atypical analgesic agent for the amelioration of severe and chronic pain.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from omega-conotoxin MVIIA
Phenotype where environments contain omega-conotoxin MVIIA
Phenotype modified by environments containing omega-conotoxin MVIIA
Human Disease Model
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