omega-conotoxin MVIIA

Term ID

CHEBI:142406

Synonyms

• omega-Conopeptide MVIIA (Conus)
• SNX-111
• ziconotide

Definition

A heterodetic cyclic polypeptide consisting of the linear sequence Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 with three disulfide bridges between cysteine residues 1-16, 8-20 and 15-25. A neuronal N-type Ca(2+) channel blocker in mammalian and amphibian brain, it blocks release of GABA and glutamate at neuronal synapses. Used as a probe for calcium channel receptors, it is selective for different receptor subtypes. A synthetic form, named ziconotide, is an atypical analgesic agent for the amelioration of severe and chronic pain.

References

• CAS:107452-89-1
• Drug_Central:2878
• PMID:16503054
• PMID:17207931
• PMID:24397285
• PMID:26662374
• PMID:26861472
• PMID:28648727
• PMID:29440821
• PMID:29635804
• PMID:30137539
• PMID:30206508

Ontology

ChEBI  ( EBI )