16,16-dimethylprostaglandin E2

Term ID

CHEBI:141046

Synonyms

(5Z,11alpha,13E,15R)-11,15-dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1-oic acid
16,16-dimethyl Prostaglandin E2
16,16-Dimethyl-pge2
16,16-Dimethyl-prostaglandin E2
9-oxo-11R,15R-dihydroxy-16,16-dimethyl-5Z,13E-prostadienoic acid
dmPGE(2)
dmPGE2

Definition

A prostanoid that is prostaglandin E₂ in which both of the hydrogens at position 16 have been replaced by methyl groups. A synthetic analogue of prostaglandin E₂, it is a potent inhibitor of pancreatic function and growth of experimental tumors. It also protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers.

References

cas:39746-25-3
lipidmaps:LMFA03010065
pubmed:10630489
pubmed:10669047
pubmed:10952078
pubmed:11208431
pubmed:11991626
pubmed:1372575
pubmed:1373359
pubmed:1604570
pubmed:1629578
pubmed:174967
pubmed:19059888
pubmed:2116342
pubmed:23996087
pubmed:3562785
pubmed:7201834
pubmed:7513369
pubmed:7616483
pubmed:7625885
pubmed:7847837
pubmed:7874263
pubmed:8225563
pubmed:8322025
pubmed:8419232
pubmed:8514255
pubmed:8613460
pubmed:9073153
pubmed:9481403

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from 16,16-dimethylprostaglandin E2

Phenotype where environments contain 16,16-dimethylprostaglandin E2

Phenotype modified by environments containing 16,16-dimethylprostaglandin E2

Phenotype affecting 16,16-dimethylprostaglandin E2

Human Disease Model