RF9

Term ID

CHEBI:140980

Synonyms

1-adamantanecarbonyl-Arg-Phe-NH2
N(2)-(tricyclo[3.3.1.1(3,7)]decan-1-ylcarbonyl)-L-arginyl-L-phenylalaninamide
NPFF receptor antagonist
RF 9
RF-9

Definition

A dipeptide formed from L-arginine and L-phenylalaninamide residues in which a hydrogen attached to the nitrogen of the α-amino group of the arginine residue has been replaced by a 1-adamantanecarbonyl group. It has been reported to be a potent and selective antagonist of neuropeptide FF (NPFF) receptors, but more recently found to be an agonist at both NPFF1R and the kisspeptin receptor (KISS1R).

References

cas:876310-60-0
pmc:PMC1635127
pubmed:16407169
pubmed:16828031
pubmed:18276024
pubmed:20160130
pubmed:21167893
pubmed:22283564
pubmed:22848794
pubmed:23291266
pubmed:25181419
pubmed:25322463
pubmed:25713426
pubmed:26259035
pubmed:26418326
pubmed:26472125
pubmed:26641552
pubmed:26862995
pubmed:26896564
pubmed:28288815
pubmed:28380582
pubmed:28746808
pubmed:28757099
pubmed:28825666
pubmed:28965655
pubmed:29727163

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from RF9

Phenotype where environments contain RF9

Phenotype modified by environments containing RF9

Phenotype affecting RF9

Human Disease Model