onalespib

Term ID

CHEBI:140592

Synonyms

• (2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone
• (2,4-dihydroxy-5-isopropylphenyl){5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydro-2H-isoindol-2-yl}methanone
• AT 13387
• AT-13387
• AT13387
• onalespib
• onalespibum

Definition

A member of the class of isoindoles that is isoindole in which the amino group has been acylated by a 2,4-dihydroxy-5-isopropylbenzoyl group and in which position 5 of the isoidole moiety has been substituted by a (4-methylpiperazin-1-yl)methyl group. A second-generation Hsp90 inhibitor.

References

• cas:912999-49-6
• drugbank:DB06306
• kegg.drug:D10719
• pdb-ccd:XJX
• pmc:PMC4638428
• pubmed:20662534
• pubmed:21538821
• pubmed:22181674
• pubmed:22714264
• pubmed:23186098
• pubmed:24156782
• pubmed:25336693
• pubmed:25349308
• pubmed:26082332
• pubmed:26248657
• pubmed:26452257
• pubmed:26627081
• pubmed:27156227
• pubmed:27197266
• pubmed:27321499
• pubmed:27673365
• pubmed:28679777
• pubmed:31638190
• reaxys:18536397

Ontology

ChEBI  ( EBI )