Search Ontology:
ChEBI

desirudin

Term ID
CHEBI:140427
Synonyms
  • 63-desulfohirudin (Hirudo medicinalis isoform HV1)
  • CGP 39393
  • CGP-39393
  • desirudin
  • desirudin recombinant
  • desirudina
  • desirudine
  • desirudinum
  • desulfatohirudin
  • desulphatohirudin
  • desulphatohirudin HV1
  • IK-HIR02
  • Iprivask
  • L-valyl-L-valyl-L-tyrosyl-L-threonyl-L-alpha-aspartyl-L-cysteinyl-L-threonyl-L-alpha-glutamyl-L-seryl-glycyl-L-glutaminyl-L-asparagyl-L-leucyl-L-cysteinyl-L-leucyl-L-cysteinyl-L-alpha-glutamyl-glycyl-L-seryl-L-asparagyl-L-valyl-L-cysteinyl-glycyl-L-glutam
  • Revasc
  • VVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIPEEYLQ
  • VVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIPEEYLQ (disulfide bridge: 6->14; 16->28; 22->39)
Definition
A heterodetic cyclic peptide composed of 65 amino acids joined in sequence and cyclised by three disulfide bridges between cysteine residues 6-14, 16-28 and 22-39. It is a highly specific inhibitor of thrombin and used as an anticoagulant in patients to prevent venous thromboembolism. Its amino acid sequence differs from natural hirudin by lack of sulfate group on Tyr-63.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from desirudin
Phenotype where environments contain desirudin
Phenotype modified by environments containing desirudin
Human Disease / Model Data
Citations
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