nepicastat

Term ID

CHEBI:139334

Synonyms

• (S)-5-aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydroimidazole-2-thione
• 5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1,3-dihydro-2H-imidazole-2-thione
• nepicastat
• nepicastatum
• RS-25560-197
• SYN117

Definition

A member of the class of 1,3-dihydroimidazole-2-thiones that is 1,3-dihydro-2H-imidazole-2-thione in which one of the nitrogens is substituted by a 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl group while the carbon adjacent to it is substituted by an aminomethyl group (the S enantiomer). It is a potent and selective inhibitor of both bovine and human dopamine β-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.

References

• cas:173997-05-2
• drugbank:DB12979
• pubmed:11034950
• pubmed:23289939
• pubmed:23303068
• pubmed:23561307
• pubmed:25257286
• pubmed:25602710
• pubmed:9283721
• pubmed:9641484
• reaxys:9425404
• wikipedia.en:Nepicastat

Ontology

ChEBI  ( EBI )