Search Ontology:
ChEBI

6beta-hydroxycortisone

Term ID
CHEBI:139269
Synonyms
  • 6beta,17,21-trihydroxypregn-4-ene-3,11,20-trione
  • 6beta-17alpha,21-trihydroxypregn-4-ene-3,11,20-trione
  • 6beta-hydroxycortisone
Definition
A C21-steroid that is cortisone bearing an additional hydroxy substituent at the 6beta-position. It is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_functional_parent
has_role
Phenotype
Phenotype resulting from 6beta-hydroxycortisone
Phenotype where environments contain 6beta-hydroxycortisone
Phenotype modified by environments containing 6beta-hydroxycortisone
Human Disease Model