Search Ontology:
ChEBI
6beta-hydroxycortisone
- Term ID
- CHEBI:139269
- Synonyms
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- 6beta,17,21-trihydroxypregn-4-ene-3,11,20-trione
- 6beta-17alpha,21-trihydroxypregn-4-ene-3,11,20-trione
- 6beta-hydroxycortisone
- Definition
- A C21-steroid that is cortisone bearing an additional hydroxy substituent at the 6beta-position. It is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.
- References
-
- PMID:10718654
- PMID:13941685
- PMID:21490593
- Reaxys:3177303
- Ontology
- ChEBI ( EBI )
- is a type of
- has_functional_parent
-
- has_role
-
Phenotype
Phenotype resulting from 6beta-hydroxycortisone
Phenotype where environments contain 6beta-hydroxycortisone
Phenotype modified by environments containing 6beta-hydroxycortisone
Human Disease Model