GSK2656157

Term ID

CHEBI:139047

Synonyms

1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)-ethanone
1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methylpyridin-2-yl)ethanone
PERK inhibitor

Definition

A pyrrolopyrimidine that is 7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine which has been substituted at position 5 by a 4-fluoro-2,3-dihydro-1H-indol-5-yl group, the nitrogen of which has been acylated by a (6-methylpyridin-2-yl)acetyl group. An orally bioavailable PERK inhibitor.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: biaryl indoles methylpyridines organofluorine compound pyrrolopyrimidine ... Show All 6 Terms

biaryl indoles methylpyridines organofluorine compound pyrrolopyrimidine tertiary carboxamide Show first 5 Terms
has_role: antineoplastic agent EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor PERK inhibitor

antineoplastic agent EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor PERK inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from GSK2656157

Phenotype where environments contain GSK2656157

Phenotype modified by environments containing GSK2656157

Human Disease Model