piericidin A

Term ID

CHEBI:138511

Synonyms

(+)-piericidin A1
2-[(2E,5E,7E,11E)-10R-hydroxy-3,7,9R,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5,6-dimethoxy-3-methyl-4-pyridinol
2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraen-1-yl]-5,6-dimethoxy-3-methylpyridin-4-ol
2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraenyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one
AR 054
Piericidin A1
Shaoguanmycin B
SN 198E

Definition

A member of the class of monohydroxypyridines that acts as an irreversible mitochondrial Complex I inhibitor that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of NADH:ubiquinone oxidoreductase

References

cas:2738-64-9
metacyc.compound:CPD0-1233
pubmed:12400692
pubmed:16277503
pubmed:16953619
pubmed:17721005
pubmed:17941090
pubmed:19138148
pubmed:22365607
pubmed:24295981
pubmed:24409990
pubmed:25437199
pubmed:25812110
pubmed:26856451
pubmed:27301663
pubmed:28217742
pubmed:9684860
reaxys:4720916

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from piericidin A

Phenotype where environments contain piericidin A

Phenotype modified by environments containing piericidin A

Phenotype affecting piericidin A

Human Disease Model