bis(7)-tacrine

Term ID

CHEBI:138435

Synonyms

B7T
bis(7)-tetrahydroaminacrine
heptylene-bis(tacrine)
N,N'-bis(1,2,3,4-tetrahydro-9-acridinyl)-1,7-heptanediamine
N,N'-di(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine

Definition

A secondary amino compound consisting of two molecules of tacrine that are linked together through their exocyclic amino groups by a heptane-1,7-diyl chain. Bis(7)-tacrine is an acetylcholinesterase (AChE)inhibitor (IC₅₀ 0.40 nM, >1,000 times more potent than tacrine). It has also been found to protect against H₂O₂ -induced apoptosis in rat pheochromocytoma cells.

References

chemspider:7828118
pdb-ccd:AA7
pubmed:10208549
pubmed:10452094
pubmed:16543809
pubmed:17449090
pubmed:17530875
pubmed:19393253
pubmed:20043893
pubmed:20199668
pubmed:20486153
pubmed:21535411
pubmed:22330749
pubmed:22553626
pubmed:23832279
pubmed:26043757
pubmed:28294041
pubmed:28571743
reaxys:7608979

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from bis(7)-tacrine

Phenotype where environments contain bis(7)-tacrine

Phenotype modified by environments containing bis(7)-tacrine

Phenotype affecting bis(7)-tacrine

Human Disease Model