JQ1

Term ID

CHEBI:137113

Synonyms

(+)-JQ1
(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-6-yl)acetate
(S)-JQ1
JQ1
JQ1 Compound
TEN-010
tert-butyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate

Definition

A member of the class of thienotriazolodiazepines that is the tert-butyl ester of [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid. An inhibitor of bromodomain-containing protein 4 that exhibits anti-cancer and cardioprotective properties.

References

cas:1268524-70-4
lincs.smallmolecule:LSM-6332
pdb-ccd:JQ1
pubmed:20871596
pubmed:23911322
pubmed:26206333
pubmed:26733615
pubmed:26791045
pubmed:26830473
pubmed:26908627
pubmed:27117003
pubmed:27292261
pubmed:27440272
pubmed:27443262
pubmed:27528027
pubmed:27531767
pubmed:27539364
pubmed:27572308
pubmed:27573714
pubmed:27758824
pubmed:27764802
pubmed:27864418
pubmed:28026145
pubmed:28059436
pubmed:28063381
pubmed:28100400
pubmed:28103888
pubmed:28105454
pubmed:28107481
pubmed:28118076
pubmed:28134933
pubmed:28143717
pubmed:28248992
pubmed:28254412
pubmed:28270499
pubmed:28275007
pubmed:28322577
pubmed:28356707
pubmed:28368473
pubmed:28418907
pubmed:28467486
pubmed:28484091
pubmed:28490802
pubmed:28504695
pubmed:28515341
pubmed:34003467
pubmed:34298684
pubmed:34757001
pubmed:34998911
pubmed:35185589
pubmed:35408939
pubmed:35517410
pubmed:35672711
pubmed:35795040
reaxys:21994154
wikipedia.en:JQ1

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from JQ1

Phenotype where environments contain JQ1

Phenotype modified by environments containing JQ1

Phenotype affecting JQ1

Human Disease Model