LY-2157299

Term ID

CHEBI:137064

Synonyms

• 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
• galunisertib
• galunisertibum
• LY 2157299
• LY2157299

Definition

A pyrrolopyrazole that is 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole which is substituted at positions 2 and 3 by 6-methylpyridin-2-yl and 6-(aminocarbonyl)quinolin-4-yl groups, respectively. A Transforming growth factor-betaRI (TGF-betaRI) kinase inhibitor, it blocks TGF-beta-mediated tumor growth in glioblastoma.

References

• CAS:700874-72-2
• KEGG:D10437
• PMCID:PMC3734332
• PMCID:PMC4055765
• PMCID:PMC4652527
• PMID:18039567
• PMID:23826206
• PMID:24868575
• PMID:25424852
• PMID:25488804
• PMID:25529192
• PMID:25573078
• PMID:26057634
• PMID:26137087
• PMID:26309397
• PMID:26526984
• PMID:26902851
• PMID:26976322
• PMID:27197172
• PMID:27509307
• PMID:27756784
• PMID:27990167
• PMID:28230858
• PMID:28405618
• PMID:28436712
• PMID:28451833
• PMID:28481241
• Reaxys:14275134
• Wikipedia:Galunisertib

Ontology

ChEBI  ( EBI )

Resources

CTD