LY-2157299

Term ID

CHEBI:137064

Synonyms

4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
galunisertib
galunisertibum
LY 2157299
LY2157299

(all 5)

Definition

A pyrrolopyrazole that is 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole which is substituted at positions 2 and 3 by 6-methylpyridin-2-yl and 6-(aminocarbonyl)quinolin-4-yl groups, respectively. A Transforming growth factor-betaRI (TGF-betaRI) kinase inhibitor, it blocks TGF-beta-mediated tumor growth in glioblastoma.

References

(all 29)

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: aromatic amide methylpyridines monocarboxylic acid amide pyrrolopyrazole quinolines

aromatic amide methylpyridines monocarboxylic acid amide pyrrolopyrazole quinolines Show first 5 Terms
has_role: antineoplastic agent TGFbeta receptor antagonist

antineoplastic agent TGFbeta receptor antagonist Show first 5 Terms

Phenotype

Phenotype resulting from LY-2157299

Phenotype where environments contain LY-2157299

Phenotype modified by environments containing LY-2157299

Phenotype affecting LY-2157299

Human Disease Model