Search Ontology:
ChEBI
LY-2157299
- Term ID
- CHEBI:137064
- Synonyms
-
- 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
- galunisertib
- galunisertibum
- LY 2157299
- LY2157299
- Definition
- A pyrrolopyrazole that is 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole which is substituted at positions 2 and 3 by 6-methylpyridin-2-yl and 6-(aminocarbonyl)quinolin-4-yl groups, respectively. A Transforming growth factor-βRI (TGF-βRI) kinase inhibitor, it blocks TGF-β-mediated tumor growth in glioblastoma.
- References
-
- cas:700874-72-2
- kegg.drug:D10437
- pmc:PMC3734332
- pmc:PMC4055765
- pmc:PMC4652527
- pubmed:18039567
- pubmed:23826206
- pubmed:24868575
- pubmed:25424852
- pubmed:25488804
- pubmed:25529192
- pubmed:25573078
- pubmed:26057634
- pubmed:26137087
- pubmed:26309397
- pubmed:26526984
- pubmed:26902851
- pubmed:26976322
- pubmed:27197172
- pubmed:27509307
- pubmed:27756784
- pubmed:27990167
- pubmed:28230858
- pubmed:28405618
- pubmed:28436712
- pubmed:28451833
- pubmed:28481241
- reaxys:14275134
- wikipedia.en:Galunisertib
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
Phenotype
Phenotype resulting from LY-2157299
Phenotype where environments contain LY-2157299
Phenotype modified by environments containing LY-2157299
Phenotype affecting LY-2157299
Human Disease Model