AP20187

Term ID

CHEBI:136847

Synonyms

• (1R)-3-(3,4-dimethoxyphenyl)-1-{3-[2-({3-[2-(3-{(1R)-3-(3,4-dimethoxyphenyl)-1-[({(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidin-2-yl}carbonyl)oxy]propyl}phenoxy)acetamido]-2-[(dimethylamino)methyl]propyl}amino)-2-oxoethoxy]phenyl}propyl (2S)-1
• AP 20187
• B/B Homodimerizer

Definition

A tertiary amino compound that is 2-(aminomethyl)-N,N-dimethylpropane-1,3-diamine in which the primary ammino groups have each been acylated by condensation with the carboxy group of 2-{3-[(1R)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy}acetic acid, the hydroxy groups of which have been esterified by condensation with the carboxy group of L-pipecolic acid, the nitrogen of which has been acylated by condensation with (2S)-2-(3,4,5-trimethoxyphenyl)butyric acid. It is a synthetic, cell-permeable ligand that can be used to induce homodimerization of fusion proteins containing the DmrB domain.

References

• CAS:195514-80-8
• PMID:17328681
• PMID:17962474
• PMID:24421317
• PMID:25928330
• PMID:27604214
• PMID:28173622
• PMID:28191782
• Patent:US6150527
• Patent:WO2012103279
• Reaxys:22811386
• Wikipedia:AP20187

Ontology

ChEBI  ( EBI )