Search Ontology:
ChEBI

atrasentan

Term ID
CHEBI:135810
Synonyms
  • (+)-A 127722
  • (+)-A-127722
  • (+)-A127722
  • (2R, 3R, 4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic acid
  • (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic acid
  • (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
  • A 147627
  • A-147627
  • ABT 627
  • ABT-627
  • ABT627
  • atrasentan
  • atrasentanum
Definition
A member of the class of pyrrolidines that is pyrrolidine substituted by 2-(dibutylamino)-2-oxoethyl, 4-methoxyphenyl, carboxy, and 1,3-benzodioxol-5-yl groups at positions 1, 2, 3, and 4, respectively (the 2R,3R,4S-stereoisomer). It is an endothelin endothelin type A receptor antagonist used to reduce proteinuria in adults with primary immunoglobulin A nephropathy.
References
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from atrasentan
Phenotype where environments contain atrasentan
Phenotype modified by environments containing atrasentan
Phenotype affecting atrasentan
Human Disease Model