amrubicin

Term ID

CHEBI:135779

Synonyms

(1S,3S)-3-acetyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2-deoxy-beta-D-erythro-pentopyranoside
(7S,9S)-9-acetyl-9-amino-7-{[(2S,4S,5R)-4,5-dihydroxytetrahydro-2H-pyran-2-yl]oxy}-6,11-dihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione
amrubicin
amrubicina
amrubicine
amrubicinum
SM-5887

Definition

A synthetic anthracycline antibiotic with molecular formula C25H25NO9. A specific inhibitor of topoisomerase II, it is used (particularly as the hydrochloride salt) in the treatment of cancer, especially lung cancer, where it is a prodrug for the active metabolite, ambrucinol.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: anthracycline antibiotic methyl ketone primary amino compound quinone tetracenes

anthracycline antibiotic methyl ketone primary amino compound quinone tetracenes Show first 5 Terms
has_role: antineoplastic agent prodrug topoisomerase II inhibitor

antineoplastic agent prodrug topoisomerase II inhibitor Show first 5 Terms
inverse has_functional_parent: amrubicinol

amrubicinol Show first 5 Terms

Phenotype

Phenotype resulting from amrubicin

Phenotype where environments contain amrubicin

Phenotype modified by environments containing amrubicin

Human Disease / Model Data

Citations