rucaparib

Term ID

CHEBI:134689

Synonyms

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
AG-14447
rucaparib
rucaparibum

Definition

A member of the class of azepinoindoles that is 1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one carrying additional 4-[(methylamino)methyl]phenyl and fluoro substituents at positions 2 and 8 respectively. It is an inhibitor of poly (ADP-ribose) polymerase and is used (as the camsylate salt) as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation.

References

cas:283173-50-2
chemspider:8107584
drugbank:DB12332
kegg.drug:D10079
lincs.smallmolecule:LSM-4947
pdb-ccd:RPB
pubmed:24900770
pubmed:25689628
pubmed:26438157
pubmed:27002934
pubmed:27087632
pubmed:27128213
pubmed:27228289
pubmed:27415012
pubmed:27515310
pubmed:27600766
pubmed:27702817
pubmed:27716873
pubmed:27866910
pubmed:27908594
pubmed:27940438
pubmed:28001384
pubmed:28057616
pubmed:28069724
pubmed:28205191
pubmed:28790837
pubmed:30830551
pubmed:30977683
pubmed:32121331
pubmed:32173049
pubmed:32241924
pubmed:32495160
pubmed:32717310
pubmed:32795228
pubmed:33053351
pubmed:33145877
pubmed:33332934
pubmed:33343988
pubmed:33369704
pubmed:33515503
pubmed:33752918
pubmed:33780687
reaxys:11556434
wikipedia.en:Rucaparib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from rucaparib

Phenotype where environments contain rucaparib

Phenotype modified by environments containing rucaparib

Phenotype affecting rucaparib

Human Disease Model