Search Ontology:
ChEBI
rucaparib
- Term ID
- CHEBI:134689
- Synonyms
-
- 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
- AG-14447
- rucaparib
- rucaparibum
- Definition
- A member of the class of azepinoindoles that is 1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one carrying additional 4-[(methylamino)methyl]phenyl and fluoro substituents at positions 2 and 8 respectively. It is an inhibitor of poly (ADP-ribose) polymerase and is used (as the camsylate salt) as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation.
- References
-
- CAS:283173-50-2
- Chemspider:8107584
- DrugBank:DB12332
- KEGG:D10079
- LINCS:LSM-4947
- PDBeChem:RPB
- PMID:24900770
- PMID:25689628
- PMID:26438157
- PMID:27002934
- PMID:27087632
- PMID:27128213
- PMID:27228289
- PMID:27415012
- PMID:27515310
- PMID:27600766
- PMID:27702817
- PMID:27716873
- PMID:27866910
- PMID:27908594
- PMID:27940438
- PMID:28001384
- PMID:28057616
- PMID:28069724
- PMID:28205191
- PMID:28790837
- PMID:30830551
- PMID:30977683
- PMID:32121331
- PMID:32173049
- PMID:32241924
- PMID:32495160
- PMID:32717310
- PMID:32795228
- PMID:33053351
- PMID:33145877
- PMID:33332934
- PMID:33343988
- PMID:33369704
- PMID:33515503
- PMID:33752918
- PMID:33780687
- Reaxys:11556434
- Wikipedia:Rucaparib
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
- inverse is_conjugate_acid_of
-
- is_conjugate_base_of
-
Show first 5 Terms
Phenotype
Phenotype resulting from rucaparib
Phenotype where environments contain rucaparib
Phenotype modified by environments containing rucaparib
Human Disease / Model Data
Citations