MI-63

Term ID

CHEBI:134602

Synonyms

• (2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-[2-(morpholin-4-yl)ethyl]-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide

Definition

An azaspiro compound resulting from the formal fusion of position 3 of 6-chloro-oxindole with position 3 of (2R,3SS5S)-3-(3-chloro-2-fluorophenyl)-5-(2,2-dimethylpropyl)-N-[2-(morpholin-4-yl)ethyl]pyrrolidine-2-carboxamide. It is a potent inhibitor of the MDM2-p53 interaction.

References

• pubmed:19707204
• pubmed:20423286
• pubmed:21725357
• pubmed:24921920
• pubmed:25181509
• pubmed:27323823
• pubmed:27729622
• reaxys:10506427

Ontology

ChEBI  ( EBI )