yanuthone K

Term ID

CHEBI:133035

Synonyms

(1R,2R,6R)-3-methyl-5-oxo-6-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-7-oxabicyclo[4.1.0]hept-3-en-2-yl acetate
yanuthone-K

Definition

A class I yanuthone that is 5,6-epoxy-cyclohex-2-en-1-one which is substituted at positions 3, 4, and 6 by methyl, acetoxy, and trans,trans-farnesyl groups, respectively (the R,R,R stereoisomer). Isolated from the filamentous fungus Aspergillus niger, it shows antifungal activity towards the pathogenic yeast Candida albicans (IC50 = 17.5 +-3.9 muM).

References

PMID:25293978
Reaxys:27991879

Ontology

ChEBI ( EBI )

Relationships

is a type of: acetate ester class I yanuthone

acetate ester class I yanuthone Show first 5 Terms
has_functional_parent: (2-trans,6-trans)-farnesol 7-deacetoxyyanuthone A

(2-trans,6-trans)-farnesol 7-deacetoxyyanuthone A Show first 5 Terms
has_role: antifungal agent Aspergillus metabolite

antifungal agent Aspergillus metabolite Show first 5 Terms
inverse has_functional_parent: yanuthone L yanuthone M

yanuthone L yanuthone M Show first 5 Terms

Phenotype

Phenotype resulting from yanuthone K

Phenotype where environments contain yanuthone K

Phenotype modified by environments containing yanuthone K

Human Disease Model