sapitinib

Term ID

CHEBI:132986

Synonyms

• 2-(4-{[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy}piperidin-1-yl)-N-methylacetamide
• 2-[4-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]-N-methylacetamide
• AZD-8931
• AZD8931
• sapitinib
• sapitinibum

Definition

A member of the class of quinazolines that is 4-amino-7-methoxyquinazoline in which the amino group has been substituted by a 3-chloro-2-fluorophenyl group and in which position 6 of the quinoline ring has been substituted by a {1-[2-(methylamino)-2-oxoethyl]piperidin-4-yl}oxy group. Sapitinib is a dual tyrosine kinase inhibitor (TKI) of epithelial growth factor receptors (EGFR) HER2 and HER3.

References

• cas:848942-61-0
• pubmed:20145185
• pubmed:24554387
• pubmed:24875132
• pubmed:24886365
• pubmed:24900741
• pubmed:25007130
• pubmed:25149507
• pubmed:26095475
• reaxys:12223131

Ontology

ChEBI  ( EBI )