dynasore

Term ID

CHEBI:132754

Synonyms

• 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
• Dynamin Inhibitor I
• N'-[(E)-(3,4-dihydroxyphenyl)methylene]-3-hydroxy-2-naphthohydrazide

Definition

A carbohydrazide resulting from the formal condensation of the hydrazone moiety of 3,4-dihydroxybenzaldehyde hydrazone with the carboxy group of 3-hydroxy-2-naphthoic acid. It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.

References

• pubmed:18413242
• pubmed:23596510
• pubmed:24367704
• pubmed:25421092
• pubmed:25550455
• pubmed:25850711
• pubmed:25878109
• pubmed:25889964
• pubmed:26063501
• pubmed:26894834
• reaxys:20640593
• reaxys:25249841

Ontology

ChEBI  ( EBI )