1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

Term ID

CHEBI:131947

Synonyms

1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-o-tolylurea
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-methylphenyl)urea
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N''-(2-methylphenyl)-urea

Definition

A member of the class of indazoles that is linifanib in which the 2-fluoro-5-methylphenyl group has been replaced by a 2-methylphenyl group. A cell-permeable 3-aminoindazolylurea compound, it acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC50 = 3 nM) as well as Flt3 and cKit (IC50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro.

References

CAS:796967-10-7
PMID:17343372
Reaxys:11008701

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic amine indazoles phenylureas ring assembly

aromatic amine indazoles phenylureas ring assembly Show first 5 Terms
has_role: EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor

EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

Phenotype where environments contain 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

Phenotype modified by environments containing 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

Human Disease / Model Data