salubrinal

Term ID

CHEBI:131923

Synonyms

(2E)-3-phenyl-N-{2,2,2-trichloro-1-[(quinolin-8-ylcarbamothioyl)amino]ethyl}acrylamide

Definition

A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α).

References

cas:405060-95-9
patent:EP2589593
pubmed:15705855
pubmed:22610062
pubmed:23178987
pubmed:23473976
pubmed:23603983
pubmed:23816340
pubmed:23824972
pubmed:24418467
pubmed:24728926
pubmed:25030410
pubmed:25157407
pubmed:25230871
pubmed:25435425
pubmed:25582550
pubmed:25619567
pubmed:25816071
pubmed:25882497
pubmed:25977571
pubmed:26021511
pubmed:26193263
pubmed:26328492
pubmed:26505387
pubmed:26743901
pubmed:26889171
pubmed:27123756
pubmed:27131989
reaxys:13925629
wikipedia.en:Salubrinal

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from salubrinal

Phenotype where environments contain salubrinal

Phenotype modified by environments containing salubrinal

Phenotype affecting salubrinal

Human Disease Model