cefatrizine

Term ID

CHEBI:131730

Synonyms

• (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(1H-1,2,3-triazol-4-ylsulfanyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (7R)-7-(alpha-D-4-hydroxyphenylglycylamino)-3-(1H-1,2,3-triazol-4-ylthiomethyl)-3-cephem-4-carboxylic acid
• antibiotic BL-S 640
• BL-S 640
• BL-S640
• BLS 640
• cefatrizina
• cefatrizine
• cefatrizinum
• SKF 60771

Definition

A cephalosporin compound having (1H-1,2,3-triazol-4-ylsulfanyl)methyl and [(2R)-2-amino-2-(4-hydroxyphenyl)]acetamido side-groups. An antibacterial drug first prepared in the 1970s, it has more recently been found to be an inhibitor of eukaryotic elongation factor-2 kinase (eEF2K), which is known to regulate apoptosis, autophagy and ER stress in many types of human cancers.

References

• CAS:51627-14-6
• Drug_Central:529
• KEGG:D02406
• PMID:1137381
• PMID:2329468
• PMID:23894823
• PMID:239917
• PMID:26776155
• PMID:29017833
• PMID:3915469
• PMID:6660858
• PMID:813573
• Patent:DE2316866
• Patent:DE2364192
• Patent:US3867380
• Reaxys:8172545
• Wikipedia:Cefatrizine

Ontology

ChEBI  ( EBI )

Resources

CTD