pneumocandin B0

Term ID

CHEBI:131609

Synonyms

(10R,12S)-N-{(2R,6S,9S,11R,12R,14aS,15S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1
L 688,786
L-688,786
L-688786
pneumocandin B(0)
pneumocardin B(0)

Definition

An echinocandin initially isolated as a very minor bioactive fermentation product of Glarea lozoyensis (originally known as Zalerion arboricola). Subsequent random mutagenesis work and optimisation of the fermentation medium permitted the industrial production of pneumocandin B0, which is used as the starting point for the synthesis of the antifungal drug caspofungin.

References

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: echinocandin homodetic cyclic peptide

echinocandin homodetic cyclic peptide Show first 5 Terms
has_role: antifungal agent fungal metabolite

antifungal agent fungal metabolite Show first 5 Terms
inverse has_functional_parent: caspofungin

caspofungin Show first 5 Terms

Phenotype

Phenotype resulting from pneumocandin B0

Phenotype where environments contain pneumocandin B0

Phenotype modified by environments containing pneumocandin B0

Human Disease Model