alisertib

Term ID

CHEBI:125628

Synonyms

4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl]amino]-2-methoxybenzoic acid
4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid
4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid
alisertib
alisertibum
MLN 8237
MLN-8237
MLN8237

Definition

An organic heterotricyclic compound that is 5H-pyrimido[5,4-d][2]benzazepine substituted by (4-carboxy-3-methoxyphenyl)amino, 2-fluoro-6-methoxyphenyl, and chloro groups at positions 2, 7 and 9, respectively. It is an aurora A kinase inhibitor (IC₅₀ = ~1 nM).

References

cas:1028486-01-2
drugbank:DB05220
hmdb:HMDB0248139
kegg.drug:D10085
lincs.smallmolecule:LSM-37184
pdb-ccd:A5B
pmc:PMC10260146
pmc:PMC11183409
pubmed:20108338
pubmed:26887042
pubmed:27502708
pubmed:27768280
pubmed:28358124
pubmed:28386317
pubmed:28594098
pubmed:30973373
pubmed:31617432
pubmed:31911485
pubmed:32608142
pubmed:33744274
pubmed:33993383
pubmed:34256279
pubmed:34435684
pubmed:34896433
pubmed:35217309
pubmed:35550115
pubmed:35652336
pubmed:35907014
pubmed:36279392
pubmed:36621626
pubmed:36694044
pubmed:36892847
pubmed:36924895
pubmed:37153900
pubmed:37355468
pubmed:37695622
pubmed:37818090
pubmed:37844921
pubmed:38639476
pubmed:38672538
pubmed:38751786
pubmed:38875929
wikipedia.en:Alisertib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from alisertib

Phenotype where environments contain alisertib

Phenotype modified by environments containing alisertib

Phenotype affecting alisertib

Human Disease Model