plerixafor

Term ID

CHEBI:125354

Synonyms

1,1'-(benzene-1,4-diyldimethanediyl)bis(1,4,8,11-tetraazacyclotetradecane)
1,1'-[1,4-phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane)
1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane
AMD 3100
AMD-3100
AMD3100
JKL 169
JM3100
Mozobil
plerixafor
plerixaforum
SDZ SID 791

Definition

An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: azacycloalkane azamacrocycle benzenes crown amine secondary amino compound ... Show All 6 Terms

azacycloalkane azamacrocycle benzenes crown amine secondary amino compound tertiary amino compound Show first 5 Terms
has_functional_parent: 1,4,8,11-tetraazacyclotetradecane

1,4,8,11-tetraazacyclotetradecane Show first 5 Terms
has_role: anti-HIV agent antineoplastic agent C-X-C chemokine receptor type 4 antagonist immunological adjuvant

anti-HIV agent antineoplastic agent C-X-C chemokine receptor type 4 antagonist immunological adjuvant Show first 5 Terms

Phenotype

Phenotype resulting from plerixafor

Phenotype where environments contain plerixafor

Phenotype modified by environments containing plerixafor

Human Disease / Model Data

Citations