Search Ontology:
ChEBI
GSK126
- Term ID
- CHEBI:124921
- Synonyms
-
- (S)-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
- 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide
- GSK 126
- GSK 2816126
- GSK 2816126A
- GSK-126
- GSK-2816126
- GSK-2816126A
- GSK2816126
- GSK2816126A
- Definition
- A member of the class of methylindoles that is 1H-indole substituted by (2S)-butan-2-yl, methyl, N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]acetamide, and 6-(piperazin-1-yl)pyridin-3-yl groups at positions 1, 3, 4, and 6, respectively. It is a potent and highly selective inhibitor of EZH2 methyltransferase (IC50 = 9.9 nM).
- References
-
- CAS:1346574-57-9
- LINCS:LSM-36365
- PDBeChem:A9G
- PMID:23051747
- PMID:26898301
- PMID:27868408
- PMID:27926488
- PMID:29070525
- PMID:29545866
- PMID:29654753
- PMID:29904056
- PMID:30737232
- PMID:31471312
- PMID:32298702
- PMID:32529327
- PMID:32606728
- PMID:32772228
- PMID:32805266
- PMID:32906688
- PMID:33085231
- PMID:33467134
- PMID:34149887
- PMID:35091962
- PMID:35864094
- PMID:36087682
- PMID:36469862
- PMID:36652457
- PMID:36734909
- PMID:37010741
- PMID:37558192
- PMID:37644332
- PMID:37989985
- PMID:38009194
- PMID:38362910
- PMID:38446700
- PMID:38530086
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
Show first 5 Terms
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Phenotype
Phenotype resulting from GSK126
Phenotype where environments contain GSK126
Phenotype modified by environments containing GSK126
Human Disease Model