delavirdine

Term ID

CHEBI:119573

Synonyms

• (N-[2-[4-[3-(1-methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl] methanesulfonamide)
• 1-(3-((1-methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)piperazine
• 2-(4-(5-methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamine
• Delavirdine
• N-(2-(1-(3-(isopropylamino)pyridin-2-yl)piperazine-4-carbonyl)-1H-indol-5-yl)methanesulfonamide
• N-[2-({4-[3-(propan-2-ylamino)pyridin-2-yl]piperazin-1-yl}carbonyl)-1H-indol-5-yl]methanesulfonamide
• N-{2-[4-(3-Isopropylamino-pyridin-2-yl)-piperazine-1-carbonyl]-1H-indol-5-yl}-methanesulfonamide

Definition

The amide resulting from the formal condensation of 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid and 4-amino group of 1-[3-(isopropylamino)pyridin-2-yl]piperazine, delavirdine is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.

References

• cas:136817-59-9
• drugbank:DB00705
• drugcentral:799
• kegg.compound:C06941
• kegg.drug:D07782
• patent:WO9109849
• pdb-ccd:SPP
• pubmed:11124228
• pubmed:11225565
• pubmed:11327199
• pubmed:11363651
• pubmed:11363709
• pubmed:11364022
• pubmed:11364099
• pubmed:11364363
• pubmed:11364481
• pubmed:11590527
• pubmed:16449090
• pubmed:21080015
• pubmed:21683601
• pubmed:21865017
• reaxys:6356813
• wikipedia.en:Delavirdine

Ontology

ChEBI  ( EBI )

Resources

CTD