diltiazem

Term ID

CHEBI:101278

Synonyms

• (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
• (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
• (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
• (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
• Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
• d-cis-diltiazem
• diltiazem
• diltiazemum

Definition

A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.

References

• cas:42399-41-7
• drugbank:DB00343
• drugcentral:897
• hmdb:HMDB0014487
• kegg.compound:C06958
• kegg.drug:D07845
• lincs.smallmolecule:LSM-2523
• patent:DE1805714
• patent:DE3415035
• patent:US3562257
• patent:US4552695
• pubmed:11937779
• pubmed:16651034
• pubmed:19167257
• pubmed:23687551
• pubmed:24261918
• pubmed:25122162
• pubmed:8369596
• reaxys:3573079
• vsdb:1863
• wikipedia.en:Diltiazem

Ontology

ChEBI  ( EBI )

Resources

CTD