zileuton

Term ID

CHEBI:10112

Synonyms

• (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea
• 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea
• Leutrol
• N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea
• N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea
• zileuton
• zileutonum
• Zyflo

Definition

A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.

References

• cas:111406-87-2
• drugbank:DB00744
• drugcentral:2862
• kegg.drug:D00414
• lincs.smallmolecule:LSM-5084
• pubmed:19309543
• pubmed:19645854
• pubmed:20204486
• pubmed:20436887
• reaxys:4869674
• wikipedia.en:Zileuton

Ontology

ChEBI  ( EBI )