nalidixic acid

Term ID

CHEBI:100147

Synonyms

1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure
1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
1-ethyl-7-methyl-1,4-dihydro-1,8-naphthyridin-4-one-3-carboxylic acid
1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
1-Ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid
3-carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one
acide nalidixique
acido nalidixico
acidum nalidixicum
nalidixic acid

Definition

A monocarboxylic acid comprising 1,8-naphthyridin-4-one substituted by carboxylic acid, ethyl and methyl groups at positions 3, 1, and 7, respectively. An orally administered antibacterial, it is used in the treatment of lower urinary-tract infections due to Gram-negative bacteria, including the majority of E. coli, Enterobacter, Klebsiella, and Proteus species.

References

cas:389-08-2
drugbank:DB00779
drugcentral:1875
kegg.compound:C05079
kegg.drug:D00183
lincs.smallmolecule:LSM-5590
patent:BE612258
patent:US3590036
pdb-ccd:NIX
pubmed:11321869
pubmed:12002106
pubmed:12399485
pubmed:12702698
pubmed:14107587
pubmed:16107187
pubmed:16423473
pubmed:16667857
pubmed:16803589
pubmed:17132068
pubmed:17631104
pubmed:18788798
pubmed:19071706
pubmed:28166217
reaxys:750515
vsdb:1880
wikipedia.en:Nalidixic_Acid

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from nalidixic acid

Phenotype where environments contain nalidixic acid

Phenotype modified by environments containing nalidixic acid

Phenotype affecting nalidixic acid

Human Disease Model